How normal cells become brain cancers

ScienceDaily (Sep. 28, 2011) ? Brain tumor specimens taken from neurosurgery cases at the University of California, San Francisco (UCSF) Medical Center have given scientists a new window on the transformation that occurs as healthy brain cells begin to form tumors.

The work may help identify new drugs to target oligodendroglioma, a common type of brain tumor, at its earliest stage, when it is generally most treatable. Any potential drugs identified will have to prove safe and effective in clinical trials, a process that can take several years.

As described in the journal Cancer Cell this month, the UCSF team found that the pool of cells from which oligodendroglioma tumors emerge normally divide "asymmetrically" by splitting into two unequal parts -- like giving birth to fraternal twins who look different and have distinct fates. When these normal cells transform into cancer cells, they switch gears and begin dividing symmetrically, essentially giving birth to identical twins instead.

"This happens early -- before the tumor forms, and it may provide a point to intervene in the process of tumor initiation," said Claudia Petritsch, PhD, an assistant professor with the UCSF Brain Tumor Research Center who led the research.

The Brain Tumor Research Center is part of the UCSF Department of Neurological Surgery, which is consistently ranked by U.S. News & World Report as one of the top departments in the world. Its doctors perform more than 1,100 neurosurgeries a year to remove brain tumors, and in the last 30 years, this work has helped to build one of the most extensive brain tumor repositories in the United States, with tissue samples collected from more than 7,800 cases of cancer.

In their research, Petritsch and her colleagues used genetically engineered mice to identify that a protein called NG2 controls this switch, and they are working on ways to target genes that regulate the process as a way of fighting oligodendroglioma and perhaps other brain tumors.

Why Divisions Matter to Cancer

Oligodendrogliomas are unusual among brain tumors because they often respond to chemotherapy drugs. However, the tumor frequently returns in a form that is resistant to chemotherapy and requires repeated surgical removal.

Petritsch and her colleagues first discovered last year that oligodendroglioma tumors derive from a type of progenitor cell called "oligodendrocyte progenitors" that proliferate in the brain throughout life. These progenitors may also play an important role when the brain is injured by multiplying rapidly and helping heal wounds.

The new studies in mice suggest that lacking an injury, these progenitors divide mostly asymmetrically, maintaining an equilibrium of these cells within the brain. Progenitors can also switch gears and divide symmetrically instead. Scientists believe that allows the brain to provide an expanded pool of cells when needed.

Using mouse models of the tumors as well as tissue samples taken from people with the disease, Petritsch and her colleagues showed that before the tumors arise, the cells preemptively make this switch, transforming from dividing asymmetrically to dividing symmetrically.

They used bioinformatics to discover that dozens of regulators of asymmetric cell division including NG2 are dysregulated in oligodendrogliomas. The Petritsch lab calls these "asymmetry proteins" and argues that if mutated they probably cause the switch to abnormal cell divisions and thereby initiate the genesis of tumors. Modulating NG2 and dysregulated asymmetry proteins pharmacologically may restore normal division modes and provide a new way to fight the cancer with drugs.

This work is supported by grants from the National Brain Tumor Foundation, the American Cancer Society, the American Brain Tumor Association, the National Cancer Institute, the UCSF Brain Tumor SPORE, the Brain Tumor Research Sobrato Fund, the Farber A and J Foundation, the Grove Foundation, the Samuel Waxman Cancer Research Foundation, the UCSF Sandler Program in Basic Science, the Swedish Society for Medical Research and Medical Research Council, and the Swiss National Science Foundation.

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The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by University of California - San Francisco.

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Journal Reference:

1. Sista Sugiarto, Anders?I. Persson, Elena?Gonzalez Munoz, Markus Waldhuber, Chrystelle Lamagna, Noemi Andor, Patrizia Hanecker, Jennifer Ayers-Ringler, Joanna Phillips, Jason Siu, Daniel A. Lim, Scott Vandenberg, William Stallcup, Mitchel?S. Berger, Gabriele Bergers, William?A. Weiss, Claudia Petritsch. Asymmetry-Defective Oligodendrocyte Progenitors Are Glioma Precursors. Cancer Cell, 2011; 20 (3): 328 DOI: 10.1016/j.ccr.2011.08.011

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/2INeFQsahoI/110928152103.htm

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The Dissimilarities of Civil as well as Criminal Law firms - JX Safety

A lot of people are not aware of what genuinely sets civil as well as criminal legal professionals apart. This is 1 good reason that they can?t genuinely go to the right person if their privileges have been mistreated. Some people accused with offenses don?t know where to go also. Both civil as well as criminal legal professionals are tasked to take care of people as well as shield their privileges within the court. Nevertheless, they differ according to the nature of legal matters that they tackle and also the people they serve.

For those who have been accused of a crime, you need to seek for the Vancouver criminal lawyer. No matter whether you?re responsible doing the crime or you?re not guilty as well as incorrectly accused, you need to uncover an attorney who could be your rep. You can find two kinds of criminal legal professionals. You?ll be able to uncover private legal professionals as well as public legal professionals. Private legal professionals might be discovered in private firms. Fundamentally, they demand higher since they concentrate on your case alone. Public legal professionals are public servants as well as may charge little charges. Whichever you select, you?re secured that your case will likely be handled properly.

Civil legal professionals are constantly on the move. They are extremely dynamic since they tackle far more people. They solve disputes between family members as well as organizations. They also make certain that disputes between two or far more parties are solved. They manage troubles concerning child adaptation, properties, mortgage loans, abortion privileges along with other social troubles. They also manage voting troubles, patent related problems along with other troubles which entail ordinary people as well as big institutions. Civil legal professionals are constantly present in their offices as well as within the courtroom. Given that they serve the civilians, they?re expected to be constantly accessible as well as approachable.

Fundamentally, becoming a criminal lawyer is far more serious. It has something to do with the most critical proper of man as well as that?s the right to live. It truly is extremely essential as well as highly sensitive. If a colleague or an acquaintance committed a serious crime, you could ask him to hire a criminal lawyer in Vancouver. It truly is extremely critical to hire reputable as well as experienced legal professionals. The qualifications of the lawyer may also impact the outcome of serious legal matters.

Source: http://www.jxsafety.com/the-dissimilarities-of-civil-as-well-as-criminal-law-firms.html

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Thousands entering Calif. schools without vaccines (AP)

SACRAMENTO, Calif. ? Last year's class of California kindergartners had a record high percentage of parents who used a personal belief exemption to avoid immunization requirements, a development that concerns state health officials.

More than 11,000 kindergartners missed at least one vaccine in 2010 because their parents decided to forgo inoculation. At nearly 2.5 percent of the state's 470,000 kindergartners, that's California's highest rate of declined vaccines since at least 1978, the year before the measles, mumps and rubella vaccine was required.

The percentage is more than double that in certain parts of the state, particularly in more affluent coastal communities in Northern California.

The public debate over childhood vaccinations has been growing throughout California, where last year a deadly spike in whooping cough cases killed 10 babies and sickened more than 9,100 people. The outbreak prompted a state law that requires middle and high school students to get whooping cough booster shots before going back to school this year.

The percentage of parents who sign vaccine exemptions based on personal beliefs has been rising steadily since 2004. The increase coincides with rising use of the Internet for information, said John Talarico, chief of the immunization branch for the California Department of Public Health.

"We really think a lot of it is due to honest, valid concern that parents do the best thing for their child coupled with misinformation that gets out through various forms of communication," he said.

He said state health officials want to study the personal-belief exemptions to better understand trends and behaviors. For now, he is hoping the trend will begin to slow, especially with media coverage of last year's whooping cough deaths.

Just last week, state health officials said the number of reported measles cases in California had reached a 10-year high of 28. Of those, 22 people were either unvaccinated or their vaccination status was unknown.

"When people can see disease around them, it generally drives them to think about the benefit the vaccine can give their children versus whatever else they hear," he said.

Vaccine statistics for this year's kindergartners will not be available until 2012.

Parents can file two types of vaccine exemptions ? a medical exemption or a personal belief exemption. The medical exemption is rarer and typically is reserved for children who cannot be vaccinated because of auto-immune disorders or allergies. It requires a doctor's signature.

For a personal belief exemption, parents are not required to supply any information to explain their decision.

Doctors and medical experts say vaccines are a reliable means of preventing illness with little risk of injury, but some parents don't buy into the safety of immunizations. They cite concerns about vaccines making their children susceptible to autism or diabetes.

In a comprehensive safety review of vaccines issued last month, the Institute of Medicine found there is no link between vaccines and autism or diabetes. The institute, part of the National Academy of Sciences, found that serious side effects of vaccines are rare and can include fever-caused seizures and occasional brain inflammation.

The increasing number of kindergartners entering school without immunizations poses a risk to others, especially children who have legitimate medical exemptions that prevent them from getting their shots, said Linda Davis-Alldritt, a school nurse consultant at the California Department of Education.

"Disease prevention is really a very important thing," she said. "These are diseases that can be very serious, and it can cause death and it can cause long lasting illnesses."

Parents receive information from schools and the Department of Education about the importance of inoculation and the dangers of unvaccinated children spreading infectious diseases to the rest of the community.

Overall immunity of a population to illness typically is achieved when 90 percent of the population is properly immunized. But Talarico, California's top immunization officer, said that can be misleading because unvaccinated children tend to cluster in pockets where like-minded parents decide to forgo immunizations.

"When we see these clusters, that represents the possibility of transmission of disease more quickly and in a more sustained fashion," he said.

A cluster of unimmunized children in San Diego led to an outbreak of measles in 2008 that infected 12 children. Nine of them had not been inoculated because of their parents' objections, while three others were too young to be immunized.

In some schools, as many as 30 percent of kindergartners are vulnerable to at least one vaccine-preventable communicable disease, according to data from the state Department of Public Health. The majority of schools have 100 percent immunization rates.

Certain areas of California have higher exemption rates than others. In Marin, Sonoma and Santa Cruz counties, more than 6 percent of incoming kindergartners in 2010 had parents file a personal belief exemption. By comparison, Los Angeles, San Francisco and Fresno counties had rates below 2 percent.

Barbara Lowe Fisher, co-founder and president of the National Vaccine Information Center in Vienna, Va., said parents sometimes decide to file the personal belief exemption form because they cannot find a doctor who will sign a medical exemption form.

"We've had families whose children have had reactions to vaccines, and some of them have become injured or even died. They want to make an independent, informed decision for their other children, and they can't find doctors who will write medical exemptions," she said.

She said the mission of her nonprofit is to prevent vaccine-related injuries or death through public education. It does not take a position on whether parents should have their children vaccinated, but it does defend a parent's right to opt out of a vaccine.

Some parents base their decision on what they hear from others or see on the Internet, rather than in consultation with a medical expert, said Catherine Flores Martin, director at the California Immunization Coalition, a Sacramento nonprofit that receives some of its funding from vaccine manufacturers.

"Parents have access to so much information on the Internet and I think a parent, even when they're really well educated, will have a hard time sifting through the credible resources versus the anecdotal stories," she said. "You can find whatever you want on the Internet to support your belief."

___

Tayefe Mohajer reported from Los Angeles.

Source: http://us.rd.yahoo.com/dailynews/rss/us/*http%3A//news.yahoo.com/s/ap/20110926/ap_on_re_us/ca_vaccine_exemptions

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Forex ? Leverage EFSF Concept Gains Traction ? International ...

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Source: http://www.financialnewstoday.org/2011/09/forex-leverage-efsf-concept-gains-traction-international-business-times/

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Choosing A Home Based Network Marketing Business | eportalsite ...

Choosing A Home Based Network Marketing Business

Article by Obinna Heche

In order to be successful in network marketing, you have to promote the marketing plan of the organization. That brings up another question, because even though you are promoting a business plan, are you not also promoting a product line? As part of the network, you are indirectly promoting the product line while directly promoting the concept of joining the organization.

That means, of course, that you have to have a product in which you believe. You are certainly not going to fare well in a network that distributes ABC Vitamins if you have tried them without success but feel great using Moms Natural Vitamins. That does not mean that within a multi level marketing organization with many products that you will never find a product you do not like but you want to avoid setting yourself up for failure by joining an organization whose entire basis is a product that you will not use.

That being said, when you begin to look around for the organization with which you desire to affiliate, make sure that you choose one whose products you would be willing to use. The basis of network marketing is, by definition, using your own products and teaching others to do the same. Does that mean you should never sell any of the products directly? No, of course not, that would be ludicrous thinking but you want to concentrate your efforts on recruiting new people for the network and making customers of those who are not interested in being individual business owners.

Based on that premise, your choice of an organization is quite pertinent to the success of your business venture, so you want to take some time making your choice. Many of the network marketing organizations on the Internet have a tendency to provide quite detailed informations, all you have to do is sign up on their website so that they know you visited and they will send you many different forms of communication. Read over everything before you make a final choice so that you know you made the right choice.

You also want to review the business plan of each organization as well as any initial investment or monetary requirements. For example, about eight years ago a network marketing organization online required you to purchase at least in products each month in order to be eligible for any bonuses. They built your downline for you but in order to be considered active, you had to spend a month.

It was a huge multi level marketing group, that might have been fine, but it was a limited product line with health and dietary products, so it would be difficult for the average person to spend that kind of money every month. These are, however, the kind of things of which you must be aware as you conduct your research and choose a network marketing organization with which to work.

About the Author

Obinna Heche. Los Angeles ? California

Delivering the best home based business ideas and opportunities so you can work at home successfully.. http://www.homeincomeportal.com/obhmy365

Source: http://eportalsite.com/choosing-a-home-based-network-marketing-business/

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Ideas For Choosing A Retirement Community

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By : Ezra Karol ??
Submitted 2011-09-24 16:46:52 Are you preparing in your retirement? After getting determined that your funds are in good standing, you might be involved with your dwelling arrangements. Even though many retirees choose to stay right where they're, many more go for retirement dwelling communities. If you're interested in doing so, you will want to choose your retirement neighborhood wisely.

Step one in selecting a retirement community involves familiarizing your self with your entire options. Did you know that you've got multiple selections? You do. Retirement communities are available in a variety of totally different formats.

Unbiased retirement communities and amenities are the preferred choice among retirees who are in good health. These are institutions where you are primarily in your own. It's like you're simply renting an apartment. Often times, the one onsite employees members are office employees, maintenance staff, and safety personnel. Many impartial retirement communities are designed to provide you with ease of living. This consists of making onsite activities, like exercise courses and arts and crafts, available.

Assisted living communities and amenities are ideal for retirees whose well being is just starting to worsen. For those who need help every now and then, an assisted dwelling retirement neighborhood could also be perfect for you. The help provided does fluctuate, however you can get help with going for a stroll outdoors, cooking, making ready for your day, or taking your medication.

Nursing houses and amenities are one other retirement possibility for these poor in health. Nursing homes are essentially hospitals with a more laidback environment. They are designed for people who can not take care of themselves. If you're researching nursing properties, you're probably a member of the family of the retiree, not him or her. When residing in a nursing home, patients are provided with round-the-clock care. It is a good different to living with family or constant home nurse care.

Persevering with care retirement services and communities are another option that you just have. This selection is one that is rising in popularity. Persevering with care retirement services and communities primarily provide residents with impartial living, assisted living, and round-the-clock care, depending on the resident's needs. These services are great for retirees who're concerned with their well being and finances. Sure, your well being may be good now, however there are no ensures with the future. Relocating and putting stress on your family isn't advised. That is why persevering with care services are often recommended.

When making your retirement community and care choice, it will be important study your needs. Do you need assistance with day-to-day actions? Are you suffering from a debilitating disease that may only proceed to worsen? If that's the case, it's best to study assisted residing communities, nursing properties, or persevering with care facilities.

Next, study your retirement neighborhood wants. Do you want to meet new folks and develop new friendships? If that's the case, make it possible for the retirement community or facility is effectively populated. Also, look at onsite activities, as they make it simpler to meet new people.

Finally, study cost and location. Always select a retirement neighborhood which you could afford. If you're the relative of a retiree who needs care, remember to hold quality in mind. Affordability is necessary, but not if high quality should be compromised. As for location, choose a retirement neighborhood that's close by your family. As you age, you will need the love and support of your loved ones more.

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The Importance of Strategic Planning by Andresespino1026 ...

People with managerial and senior executive jobs are often on the lookout for means to improve their section?s functionality and get ahead for the company?s competition. These tactical maneuvers are part of strategic planning and are a vital process in sustaining an organization. Allow me to share a few reasons why strategic planning is vital http://www.gamechangerdnas.com .Concern SolvingComing up with a strategic program brings out the challenges plaguing a department or the firm in basic. Sometimes when a concern arises, the organisation calls for this type of a meeting. The planning team points out crucial problems, realizes shortcomings and strengths and then maps out an action method.Long-Term VisionStrategic ideas are made with an finish objective in mind. These designs for the future can take decades to accomplish along with a 5-year or 10-year strategy is defined accordingly. As time progresses and changes are made, these strategies may well be adjusted to maintain with all the finish objective.Priority Ranking and Decision DoingThroughout brainstorming meetings, the committee suggests a lot of action options and goals. Some remedies could require a change in home business practice or policy. Once a consensus is accomplished, the group identifies priority action options and goals and tends to make choices on practices and policies http://www.gamechangerdnas.com .IntegrationThe common desire for your firm to progress and develop brings together the most people that are instrumental for this change. Key personnel who are element of the strategic planning, specifically many with managerial and senior executive jobs, take ownership on the ideas and get their individual sections to contribute to it.Budget DistributionStrategic programs will need to encompass all areas in the internet business. This is certainly why funds meetings are usually held after all the action ideas and initiatives had been agreed upon. Once the company has decided on what can be a priority, deciding on a budget is simplier and easier and with fewer protests http://andresespino1026.skyrock.com/3033797454-The-Importance-of-Strategic-Planning.html .Continuous ImprovementThe progress of a strategic method is periodically checked and measured. Whenever new issues crop up, they can be incorporated into an current approach or give cause for the new a single. Departmental efficiency can be monitored by way of these ideas and an annual assessment could necessarily mean an incremental improve for reached goals or a change of plans should the original a single is inefficient.

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A Guide to Buying Cheap Make Up ... - Beauty, Health and Fitness

Buying cheap cosmetics online is not as risky as many may think it is. It is definitely worth doing if you have used the products before, as you can usually guarantee to find them cheaper. Although, if you are buying a product you have never used before you may be more concerned. But don?t be! Buying cheap cosmetics online is extremely easy.

Some cosmetic brands sell really well on the internet, such as Stargazer and Crazy Colors. The Stargazer nail polish is their best seller, and no high street store sells them as cheap. Crazy Colours hair dye are also just as popular online. You can find some great deals on the internet on other cosmetic brands if you look in the right places.

Look for group coupons to help get you a discount. These are coupons that provide you with discounts on various products daily. You can get as much as fifty percent off on certain products. You will usually need to sign up with the website for these coupons and they will email you the deals, but you can also check websites regularly. These usually require a minimum amount of people buy the product for everyone to get a discount, similar to a wholesale price.

E-commerce websites are a great way to get cheap cosmetics. Since these websites have no overhead costs or staff, they are able to have lower mark-ups on their products. This also means that most products are cheaper when bought online as compared to when bought in a physical store. Since most websites usually buy directly from the manufacturers, they get wholesale prices. This means that they buy in bulk to get a lower rate per product, and they usually transfer this to the client which means you can get cheaper prices on these websites.

The only thing you need to be aware of is that buying from a reputable website is the only way you can avoid scams. Most websites have cheaper shipping options too since they do not ship the box the product comes in and save on shipping costs because of this. Packaging for many cosmetic products is bulky, and can increase shipping costs which is why many online retailers will remove this before shipping the product.

When buying online, make sure you find out how old the stock is to avoid being scammed. You should also use a service like PayPal where you can avoid giving your personal credit card information to the website owner. You can also ask PayPal to stop, or refund, a payment if you have been scammed. Many online websites have a solid refund policy, so read up on this before you order. They will usually give you a time period in which you can return the product, unopened or sometimes opened too, if you don?t like it.

Many online websites have annual sales. These can be around specific holidays or just dates that the website will announce. They usually have a sales page which you can visit to see which items are available for cheaper prices. This could be because these are going out of fashion or because it?s older stock. Websites also have discount codes that they will email to their subscribers that can allow you to get free shipping or a percentage off the price. You can also score a discount if you buy a certain amount and most websites offer free shipping over a certain amount.

Also keep an eye out via social media on your local malls and cosmetic stores since at specific times throughout the year they will sell the older stocks for cheaper rates. This is usually after the holidays and between the various seasons. They will announce this on their websites as well as any social media accounts they have. You usually need to be a subscriber or give them your email address to get this information. You can sometimes also leave your phone number with the store to get an SMS when the sales start.

Buying cheap make up like stargazer nail polish or crazy colours products is as simple as educating yourself on how to find the best discounts. You should stay up to date on the latest fashion news. Even high-end cosmetics brands have sales throughout the year, and all you need to do to be aware of these is to sign up with the website to get frequent updates. Maintaining your beauty arsenal at a low cost has never been as easy as it is now with all the websites and discounts available. All you need is your credit card or a PayPal account to shop at most websites.

Source: http://www.akcesoria-kosmetyczne.pl/beauty-news/a-guide-to-buying-cheap-make-up-online-2/

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Lake Havasu Boasts Exploding Real Estate | SPORT LIVE STREAM ...

Lake Havasu Boasts Exploding Real Estate

Lake Havasu City, AZ (PRWEB) October 8, 2005

The Lake Havasu real estate market is exploding like most around the country. This market is somewhat unique because of the small town feel and the limited land space that can fall inside the Lake Havasu city boundries. This area is on the west side of Arizona and borders along the Colorado River for about a 25 mile stretch. North of Parker Dam, and south of Highway 45, this hotspot for real estate and home buying has seen new bounds in recent years. The good family feel and small town sense has made this area a demand for single families to move in and call home.

With extreme weather conditions in the summer, Lake Havasu stays mostly warm and dry all year round. The Lake Havasu real estate market can be your next choice for a vacation home, or a year round residence. Summer recreation includes watersport competitions, boating, fishing tournaments and plenty of fun in the sun with water nearby. Winter recreation could include offroading on desert trails with your ATV?s & motorcycles. Plenty of trails to hike and desert wildlife to see, as well as public shooting ranges. Fishing can be done year-round as Lake Havasu is full of Bass and Catfish. Public docks along shorelines make fishing access easy. The Lake Havasu community is very condusive to family living, with 4 elementary schools, 2 jr. high schools and 1 high school. There are organized youth sports programs for the kids from soccer to Pop Warner football and cheerleading to gymnastics.

Local realtors including http://www.cathyjanecek.com have been setting record numbers in sales over the last 3 years. Most recently in September 2005 when 2nd quarter stats were in, realtors combined have over ,000,000 in property sold and exchanged hands for 2005, and the pace does not seem to be slowing down.

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Anti aging testosterone hormones replacement therapy for health ...

Number of View: 81

Is there a link between obesity, aging, diabetes, and testosterone? The possibility of being obese increases as a person aged. Aging is always associated with accumulation of visceral fat for both genders (Klatz & Goldman, 2004). Your energy intake or fat intake may drop, increase, or remain unchanged, as you grow older. The highest prevalence is in the age of 60 due to an increasing sedentary lifestyle. Obese people tend to lose their testosterone to their fat cells.

The body needs correct balance and rhythm of its different hormones to be able to function in its optimum. Men and women need estrogen for optimum brain and bones function. DHT or Dihydrotestosterone is the most potent form of testosterone (Rashid, 2010). Some medications such as cancer medications may block the conversion of testosterone into useful DHT?s. Testosterone levels are highest in the morning but lowest at night.

Benefits of balanced?testosterone

The testosterone levels of women is only 1/12^th of that of men. The testosterone is the main hormone secreted in the testes and produced by the testicles. The major benefits of testosterones are (Klatz & Goldman, 2003)

• Improves sexual desire and aggressiveness
• Promotes libido
• Stimulates and promotes the function and growth of certain organs
• Promotes protein anabolism and prevents protein catabolism
• Stimulates sperm production
• Regulates prostgladin production and keep the prostate under control

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The body uses protein to build muscle, and promote bone density as well as skin cells rejuvenation. The additional benefit of testosterone is improving the cognitive functions of an individual. However, for women, taking testosterone to defy the effects of aging and menopause but might include increasing masculinization among women such as developing deeper voice, body hair growth, and increase of heart disease (Klatz & Goldman, 2003).

Balancing your hormones using bioidentical hormone replacement prevents old age diseases from getting you. However, the bodybuilders tarnished the reputation of hormones replacement by using synthetic testosterone into their bodies (Aziz, 2010). The TRT or testosterone replacement therapy provides potent anti aging effects with tremendous benefits. The best age to start testosterone replacement is 40s. You need to see a doctor and monitor your testosterone levels.

DHEA hormones

You are not able to build your muscle without testosterone. It is important that you keep you muscles toned. DHEA is the most prevalent hormone of the body. People demonstrate highest longevity with higher DHEA. The ovaries produce about 40% of the DHEA while 60% are being produced by the adrenals (Platt & Farina, 2004). DHEA prevents bad cholesterol from oxidizing, promotes efficient functioning of the immune system, and prevents cancer, heart diseases, and arthritis. Although you can easily buy this hormone over the counter, you need to know and monitor your hormone levels correctly and use it only when you have a deficiency.

References

Aziz, M. (2010). The Perfect 10 Diet. Il:CumberlandHouse.

Klatz, R. & Goldman, B. (2004). Anti aging therapeutics Volume 6. Il: AmericanAcademyofAntiAging Medicine.

Klatz, R. & Goldman, R. (2003). The new anti aging revolution: Stopping the clock for a younger, sexier, happier YOU. NJ: Basic Health Publications Inc.

Platt, M. E. & Farina, M. (2004). Natural hormone therapy for men, women and children. Ca: We Publish Books.

Rashid, S. (2010). Hormones explained: Anti aging medicine, bioidentical hormone replacement, and the controversies.USA: Trafford Publishing.

If you like the information contained in this article, you may want to donate here for research efforts Get sexy, lose fats, work out your body curves, get flat abs, and look HOT! If you think you need to order articles for your website optimization page ranking strategy, please contact Shirley Bongbong +639176283668 researchwrites@gmail.com. Go for flat abs, lose weight quickly, be smart, BE HOT!

Source: http://cancerhealth.co/anti-aging-testosterone-hormones-replacement-therapy-for-health/

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Wambach leads US

/

By ANNE M. PETERSON

updated 2:14 a.m. ET Sept. 23, 2011

PORTLAND, Ore. - Abby Wambach made the most of her last match before a little rest and relaxation.

The veteran on the U.S. women's national team scored two goals in a 3-0 victory over Canada in a friendly at Jeld-Wen Field on Thursday night.

The exhibition was the second of a two-match Celebration Series to thank stateside fans for their support of the U.S. women's team during the thrilling run in the Women's World Cup in Germany this summer. The U.S. women faced Japan in the final but ultimately lost on penalty kicks.

After Thursday night's match, both the United States and Canada were going to take some time off before preparations for Olympic qualification begin.

"This is the last game for us for the season, so we wanted to go out with a win," Wambach said. "We wanted to give the fans something to cheer about."

The teams played to a 1-all draw in the opening match in Kansas City this past Saturday. Wambach converted an early penalty kick to give the United States the lead until Melissa Tancredi tied it late in the first half. The result ended Canada's seven-match losing streak to the U.S. women.

U.S. coach Pia Sundhage has experimented during the series with a one-forward system, playing Wambach up front.

Canada, meanwhile, has been adjusting to new coach Jon Herdmann after a disappointing World Cup. The sixth-ranked Canadians lost to Germany, France and Nigeria to exit after the first round.

The two teams will start training again in November and December. The top two teams from the CONCACAF qualifying tournament, scheduled for Jan. 19-29 in Vancouver, British Columbia, advance to the London Games. The U.S. will compete along with Canada, Mexico, three teams from the Caribbean and two teams from Central America.

Hope Solo wore the captain's armband on Thursday night to commemorate her 100th cap, earned in the World Cup semifinal against France.

Solo, who is competing on "Dancing with the Stars," was a fan favorite at Jeld-Wen Field, home of the Portland Timbers. She acknowledged the support with a wave when she was subbed out in the second half for Jill Loyden.

But the crowd went wild for Megan Rapinoe, who played at the University of Portland. Twice in the first half she leveled what looked like winning strikes on the net, and twice she hit the crossbar. After the second, she threw her hands up in frustration.

"That's football, I guess," Rapinoe said afterward. "We got the goals in the end."

Wambach saved the day for the United States. She scored an unassisted goal in the 63rd minute and added another goal from out front in the 70th minute. That gave her 125 career goals in international competition. Fans implored for one more by chanting: "Wambach Hat Trick!"

Alex Morgan added the final goal in the 92nd minute.

A crowd of 18, 570 attended the match in Portland, which proclaimed itself Soccer City, USA, back in the mid-1970s when it embraced the Timbers' early success in the North American Soccer League. The city's support of the game has grown throughout the years with the Portland Pilots' success, and currently with the Timbers' leap to Major League Soccer this season.

The Portland Pilots women's team won NCAA titles in 2002 and 2005.

In addition to Rapinoe, U.S. defender Stephanie Cox also played for the Pilots, as did Canadian midfielder Sophie Schmidt. Christine Sinclair, a star on the Canadian national team, did not play in the exhibition series.

"They have such phenomenal players," Schmidt said of the U.S. team, "that sometimes they just have a little magic."

Herdmann said he's happy with what he's seen in his short time with Canada.

"The biggest thing is we have a good foundation and good people to work with," he said.

Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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Stoke battles to draw with Man U

Euro roundup: Premier League leader Manchester United surrendered its perfect start to the Premier League season by drawing 1-1 with Stoke as Manchester City and Chelsea both claimed victories to narrow the gap at the top on Saturday.

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Wambach leads US

Abby Wambach scored twice and the U.S. women's national team beat Canada 3-0 in a friendly Thursday night.

Source: http://nbcsports.msnbc.com/id/44635777/ns/sports-soccer/

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UFC 135: Did Koscheck end Hughes? career with first-round TKO?

It's been a rough 18 months for the UFC's building blocks. Chuck Liddell and Randy Couture are now retired after suffering bad knockouts in their final fights. Now Matt Hughes may have to join them after falling badly against Josh Koscheck as the victim of a first-round knockout at UFC 135 in Denver.

Just Liddell like did in his final fight against Rich Franklin, Hughes was more than holding his own against the younger Koscheck. But when older fighters get popped with a good shot, they can't take it like they used to.

[Related: Complete UFC 135 recap]

Hughes landed some good shots and targeted Koscheck's right eye with some good jabs, but everything turned when he absorbed some nasty right hands in the final minute of the round. Hughes hit the floor in the final seconds. Koscheck jumped on top and poured it on. He landed two big hammer fists with five seconds left and Hughes went limp.

Hughes wouldn't commit to retiring, but appeared both emotional and really frustrated during his postfight conversation with UFC analyst Joe Rogan.

"I'm not retiring," Hughes said. "I'm going to tell the UFC to put me up on shelf and we'll see what happens after that."

This makes it two straight first-round KO or TKO losses for Hughes, the UFC Hall of Famer and two-time former champ. He lost to B.J. Penn in just 21 seconds at UFC 123.

[Related: Jones defends light heavyweight title in convincing fashion]

Koscheck (16-5, 14-5 UFC) is one of the bigger villains in the sport, so Hughes got a huge ovation from the fans at the Pepsi Center. If this was his last fight, he got a great sendoff in his record 26th appearance in the Octagon.

"I loved the crowd support when I came out," said Hughes.

Koscheck talked a lot of trash before the fight claiming that Hughes had been ducking him for years, but he was nothing but respectful after the victory.

"Thanks to Matt Hughes for taking this fight late in his career. He's a legend. I'm really happy that I had the opportunity to fight a legend like Matt Hughes," said Koscheck.

[Related: After yet another thorough win, can anybody stop Jon Jones?]

Hughes was the UFC welterweight champ on two separate occasions from 2001-06, piling up a 12-1 record during that period.

This was a must win for Koscheck, since he had everything to lose. Koscheck dropped a title shot against Georges St-Pierre, the current UFC 170-pound champion back in April. He had the orbital bone around his right eye broken. Koscheck went on the shelf for three months and had to limit all physical activity. He was targeting Nov. 19 for his return when he got the call less than three weeks ago to fill in for Diego Sanchez against Hughes on this card.

"It was actually nice being on shelf. I got to focus on other areas. I'm growing as a person and as a fighter," said Koscheck.

Other popular stories on Yahoo! Sports:
? Dream turning into Japanese MMA nightmare
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Source: http://sports.yahoo.com/mma/blog/cagewriter/post/UFC-135-Did-Koscheck-end-Hughes-career-with-fi?urn=mma-wp7285

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Radiation boost for artificial joints

ScienceDaily (Sep. 22, 2011) ? A blast of gamma radiation could toughen up plastic prosthetic joints to make them strong enough to last for years, according to researchers in China writing in the current issue of the International Journal of Biomedical Engineering and Technology.

Whole joint replacement, such as hip and knee replacement, commonly use stainless steel, titanium alloys or ceramics to replace the damaged or diseased bone of the joint. Non-stick polymer or nylon is usually used to coat the artificial joint to simulate the cartilage. However, none of these materials are ideal as they produce debris within the body as the joint is used, which leads to inflammation, pain and other problems.

Now, Maoquan Xue of the Changzhou Institute of Light Industry Technology, has investigated the effect of adding ceramic particles and fibers to two experimental materials for coating prosthetic joints, UHMWPE (ultra-high-molecular-weight polyethylene) and PEEK (polyether ether ketone). Alone neither UHMWPE nor PEEK is suitable as a prosthetic cartilage materials because both crack and fracture with the kind of everyday stresses that a hip or knee joint would exert on them. The problem is that the long polymer chains within the material can readily propagate applied forces causing tiny fractures to grow quickly and the material to fail.

Xue has now demonstrated that by adding ceramic particles to the polymers and then blasting the composite with a short burst of gamma-radiation it is possible to break the main polymer chains without disrupting the overall structure of the artificial cartilage. There is then no way for microscopic fractures to be propagated throughout the material because there are no long stretches of polymer to carry the force from one point to the next. The resulting treated material is thus much tougher than the polymer alone and will not produce the problematic debris within a joint that might otherwise lead to inflammation and pain for the patient.

Xue adds that the treated composite materials might also be more biocompatible and so less likely to be rejected by the patient's immune system on implantation. He suggests that the particular structure of the composites would also be receptive to addition of bone-generating cells, osteocytes or stem cells, that could help a prosthetic joint be incorporated more naturally into the body.

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Story Source:

The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by Inderscience Publishers, via EurekAlert!, a service of AAAS.

---

Journal Reference:

1. Maoquan Xue. Research on polymer composites of replacement prostheses. International Journal of Biomedical Engineering and Technology, 2011; 7 (1): 18 DOI: 10.1504/IJBET.2011.042495

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2011/09/110922134544.htm

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Berry Painful: Actress Breaks Foot on Movie Set

Halle Berry knows all about casts. But typically the actress is a part of them in multi-million dollar films, not donning one of them on the lower portion of her leg!

Unfortunately for the actress, though, (and for anyone forced to read that pun-heavy intro) the Oscar winner broke her foot on the set of latest film, Cloud Atlas. The accident took place in Spain, while Berry was "walking in Mallorca on a day off from filming," according to a statement by Warner Bros.

Adds the studio: "Production has adjusted their schedule and will continue filming."

This isn't the first time that shooting on this movie has caused a problem for Berry. She fought ex-boyfriend Gabriel Aubry in court over bringing their daughter with her to Europe and won.

[Photo: Fame Pictures]

Source: http://www.thehollywoodgossip.com/2011/09/berry-painful-actress-breaks-foot-on-movie-set/

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Nintendo: Knowing About Their New Game System | Oval Egg Articles

This article is about "Nintendo: Knowing About Their New Game System". Not lots of citizens recognize concerning "Console Systems" subject for the reason that media has not bothered as well as public associated with this topic have not been vocal enough. Nevertheless that's changing nowadays, more people are coming to identify regarding Console Systems because of proliferation of media outlets. It is highly suggested that you take your time reading through this piece of writing instead of speed reading it, which might lead to several missed points.

Abraham David wrote this article. If you would like to take this write-up please link back to this page. Article on "Nintendo: Knowing About Their New Game System" starts after this.

Article Starts from Here:

With all the different game systems coming out of the market, people have been trying to find out which one is better. The latest technology integrated in today?s newest game systems have been keeping people debating about which game system is better and which one should be considered as the best game console ever made.

Wii is one of the latest game systems ever released in the market today and by far, it is one of the most popular game systems available. Developed by Nintendo, people will surely buy this game system.

Nintendo is one of the known video game system manufacturers. This company developed Wii as well as other popular game consoles. Nintendo developed the Nintendo Entertainment System or NES where it is considered as the best selling game system of all time. The next game system Nintendo developed is the Super NES as well as GameBoy, GameBoy Advanced, Nintendo 64 and the GameCube.

Wii is the latest addition in the Nintendo entertainment line and the company claims it will revolutionize the way people see quality entertainment. In the past, Nintendo was seemingly boxed out by other competitors in the video gaming console industry. However, with the Nintendo Wii, it appears that Nintendo have bounced back into the competition against other large companies in the video gaming console industry.

Nintendo Wii has been in the development process for quite some time now and many people are now awaiting the full release and introduction of Wii in the market. The company is also hopeful that the release of Wii will allow Nintendo to keep up with the ever growing demands of people for quality entertainment.

Nintendo Wii is a sleek rectangular box available in different colors. Nintendo?s concept of making it simple and effective still stays the same. Unlike the GameCube though, the Nintendo Wii has taken a more modern turn and beneath the sleek outer shell, it houses a very powerful machine that people will really want to purchase.

Wii promises that it will revolutionize the way people look at gaming console. This particular console will bring a whole new gaming experience for lots of people in the world. So, you may now be asking about the features of this most anticipated gaming console.

Part of the feature of Wii is a simple remote control that looks just like any other TV remote control. However, it contains motion sensor that will be utilized in the game play aspects. For example, the new game titles for the Wii, such as Legend of Zelda: Twilight Princess will take advantage of the new controller technology to provide the player an effective way to aim.

Wii also has a great hardware feature that can make the latest gaming console available in the market today seem like amateurs and can effectively compete with the upcoming and also anticipated release of other gaming consoles developed by other big names in the video gaming system industry.

Wii is integrated with a PowerPC CPU (Broadway) that is made with a 90nm SOI CMOS process. The CPU inside Wii was developed and manufactured with IBM and the GPU was developed with ATI.

Warning: Anything in this composition is individual opinion of its writer on "Nintendo: Knowing About Their New Game System", you have to carry out your own exploration to come up with correct facts. You should seek advice from a specialist of this field. OvalEgg.com is not responsible for any damages of any kind that may arise from applying information contained in this article.

Like the GamCube, Wii also has four Wii remote controllers that can communicate with Wii. This also features a bay for an SD memory card. Wii also has an AV Multi-output port for component, composite or S-Video.

Another great feature of Nintendo Wii is the WiiConnect24. This particular console can communicate with the internet even if the power is turned of. This means that even if the system is idle, it can deliver new surprises or game updates. Wii users can connect wirelessly by using IEEE 802.11 or a USB 2.0 LAN adaptor.

If you like your GameCube games, you can still play with it using Wii. All GameCube discs are compatible to Wii. It can also support single or double layered 12mm optical discs.

There are also the features in Wii called the Wii Channels. This will enable you to change from gaming to other forms of entertainment. You can surf the internet with Wii on the internet channel, catch up with the latest headlines on the news channel, edit pictures and videos that you took with your digital camera in the photo channel, draw 3D caricatures of you and your friends in the Mii channel, and take a look at the latest weather update wherever in the world with the forecast channel.

With all of these features, you can be sure to expect that Wii will be one of the hottest selling gaming consoles in the market.

Thanks for reading this article. You have to link to this page if you want to take this article any reason. I hope you liked what I wrote on "Nintendo: Knowing About Their New Game System". I would be delighted to know what you think about it, negative or positive. Please put down a comment below and show me you are alive.

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From worst to first! D-backs win NL West

Arizona defeats defending champ SF to complete improbable run to division title

Ross D. Franklin / AP

Arizona's Justin Upton celebrates?after the Diamondbacks defeated the San Francisco Giants 3-1 to win the National League West title on Friday night.

By JOHN MARSHALL

updated 2:09 a.m. ET Sept. 24, 2011

PHOENIX - Kirk Gibson sauntered out onto the field in his familiar, half-hunched gait, stopping at a spot on the grass just outside the third base bag.

With hundreds of fans still lingering long after the final out, Gibson pumped his fist as they pumped him up with a chant of "Gibby!"

Known as a gritty winner as a player, Gibson had guided Arizona Diamondbacks to a division title in his first full season as manager.

Yes, this was sweet.

Playing with the never-give-an-inch intensity of their manager, the Diamondbacks completed an improbable run to their first NL West crown in four years, beating San Francisco 3-1 Friday night when rookie Paul Goldschmidt lined a two-run triple off Sergio Romo in the eighth inning.

"I don't care if it's your first year or your 10th year, it's what you set out to do," Gibson said.

The Diamondbacks completed their worst-to-first turnaround in raucous fashion, rallying to beat the Giants with Chase Field buzzing as it rarely did over the past couple of seasons.

It's no surprise, really.

Arizona has been coming from behind all season, whether it was from early-season predictions of another last-place finish or down a run in the late innings.

And, really, to do it again in the clinching game was the only fitting way for the Diamondbacks close it out.

Ryan Roberts got the go-ahead burst started with a double off Matt Cain (12-11) and Goldschmidt capped it with his first career triple to the corner in right.

David Hernandez (5-3), as he has all season, did his job in the setup role, striking out two after allowing a one-out single in the eighth. J.J. Putz, the closer and set-the-example veteran in the clubhouse, finished it off with his 44th save, sending the Diamondbacks pouring onto the field and the fans into an uproar.

A year after going 65-97, Arizona is 91-66 and heading to the playoffs.

"These are the moments you live for," said Diamondbacks center fielder Chris Young, who squeezed the last out.

The Giants are still alive, but just barely.

With the loss, the defending World Series champions are five games behind Atlanta for the NL wild-card spot with just five games left despite Orlando Cabrera's first homer in 124 at-bats since being traded from Cleveland.

"We are breathing. Five games left, we are still breathing," Giants manager Bruce Bochy said. "That is why there is no need to talk. We've still got baseball."

Christian Petersen / Getty Images Arizona's Ryan Roberts, left,?and Justin Upton celebrate after scoring against the San Francisco Giants during the eighth inning on Friday.

Behind Gibson's attention-to-detail approach and with a roster of players who seemed to take turns coming through in the clutch, Arizona celebrated its first division crown since 2007 by mobbing Putz near the plate. Fireworks shot out of the scoreboard after Young pulled in the final out and the Diamondbacks, after hugging and shaking hands on the field, stopped to acknowledge the fans from just above the dugout.

Champagne flowed inside the clubhouse and out, with a handful of players returning to shower their families, friends, a few people in the front row. Some of the Diamondbacks even went for a celebratory dip, splashing around the only-in-Arizona pool behind the wall in right-center after rounding the stands for high-fives with their fans.

"This is unbelievable," Roberts said.

It sure was.

Predicted to be another also-ran after a pair of 90-loss seasons, Arizona started the season on a downturn, already 6? games out of first by the end of April.

Then something clicked.

Arizona went through a magnificent May, closing the month 15-3 to take the NL West lead, and stayed near the top through July. The Diamondbacks seized control of the division at the end of August into September, going up by as much as 9? games before San Francisco came charging back with an eight-game winning streak.

But after winning three of four to start this week, Arizona found itself on the cusp of its first NL West title since 2007, needing to beat the Giants just once in the weekend series to pop the corks.

As they have all season, the Diamondbacks had to rally to get the clincher.

Arizona starter Joe Saunders was hit hard and often, but gave up just one run ? on Cabrera's solo homer in the fifth ? on nine hits in seven innings to keep Arizona close.

Cain was 6-1 with a 2.83 ERA his previous eight starts against the Diamondbacks and again had them baffled early, getting them to swing over his big-breaking curveball or pound it into the ground.

Playing with the same fighting spirit they have all season, Arizona finally got to Cain in the seventh inning, when the right-hander walked Goldschmidt with one out and Young followed with a line-drive double to the wall in left-center to tie the game at 1-all.

"They are a team that really does play until the end," said Cain, who allowed three runs on five hits in 7 1-3 innings. "They find different guys each night to spark plug the offense."

This time it was Goldschmidt, who started the season in Double-A.

With Roberts on third and Justin Upton on first after an intentional walk, Goldschmidt took and inside-out swing and sent the ball rattling around in the right-field corner. Roberts scored easily and Upton made it around as the ball clambered around off the odd angles.

Chase Field erupted in a roar after Goldschmidt's hit, which was only the prelude to the celebration that would come later ? one Arizona fans had been waiting four long years for.

"This is what I was hoping to do when I woke up this morning," Putz said.

He and about 42,000 other people.

Notes: Giants RF Carlos Beltran had a not-so-glamorous moment in the sixth inning, falling face first in the dirt after stepping on his bat while trying to run out a grounder. ... Saturday's game between the Giants and Diamondbacks is a sellout. ... RHP Ian Kennedy will go for win No. 21 against the Giants in the middle game of the series. He's allowed one run or less in 16 starts this season after matching a career-high with 12 strikeouts in eight scoreless innings against Pittsburgh the last time out. ... Rookie LHP Eric Surkamp is expected to pitch for the Giants after having his start pushed back a day to line up Cain to pitch in the season finale.

? 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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Brewers?win NL Central title

Ryan Braun hit a three-run, go-ahead homer in the eighth and the Milwaukee Brewers beat the Florida Marlins 4-1 on Friday night to win their first division title since 1982.

From worst to first! D-backs win NL West

??The Arizona Diamondbacks completed an improbable run to their first NL West crown in four years, beating San Francisco 3-1 Friday night when rookie Paul Goldschmidt lined a two-run triple off Sergio Romo in the eighth inning.

Source: http://nbcsports.msnbc.com/id/44649813/ns/sports-baseball/

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chris - TAX ADVISOR Offshore Companies Rental Tax Exposure

Posted: Mon 19 Sep, 2011 6:00 am | Viewed: 334 times

Over the past year we have been receiving a steady stream of inquiries from readers, agents and property owners about just what is the legal rental tax liability for owners who use an offshore holding company.

We spoke to the firm Phuket office of Duensing and Kippen who are tax and legal advisors who have given the following explanation -

"The use of off-shore entities, such as a company incorporated in the British Virgin Islands ("BVI") to own real estate is not uncommon in Thailand. One reason often cited by investors using such entities organized under foreign law for such purpose is that they believe it will result in significant tax savings. Whereas this may be true with regard to any tax applicable to the "sale" of the real estate by way of sale of the off-shore entity itself, it may not be true with regard to other potential tax liabilities. This article will analyze the tax consequences of an off-shore entity renting out real estate it owns in Thailand.

In general, juristic persons "carrying on business in Thailand" are subject to corporate income tax ("CIT") at the basic rate of 30%. CIT is applicable whether these entitles are incorporated under Thai law or some other foreign law. Entities organized under Thai law are subject to CIT on their worldwide income. However, entities organized under a foreign law are only subject to CIT if such income results from "carrying on business in Thailand".

If an entity incorporated under foreign law that is not "carrying on business in Thailand", but receives payment of assessable income from or within Thailand, such payment is subject to a withholding tax ("WHT") at a rate 10% or 15% depending on the type of payment, for example as follows:

INCOME DERIVED FROM: WHT RATE:

Service 15%

Interest 15%

Royalties 15%

Dividends 10%

Rent 15%

Liberal professions 15%

Where the recipient of assessable income is an off-shore party, the Revenue Code of Thailand ("RC") places the liability for filing the applicable WHT return and submitting the tax payment itself on the payer of the assessable income; in our rental income example, the lessee of the real estate owned by the off-shore entity.

Thus, tax liability for such rental income depends on whether or not the off-shore entity is deemed to be "carrying on business in Thailand". The RC does not define "carrying on business in Thailand". Section 66, paragraph 2 of the RC states that juristic companies or partnerships organized under foreign laws and carrying on business in Thailand are subject to the same tax as those organized under Thai law, but only with respect to income arising from or in consequence of the business carried on in Thailand. In addition, Section 76bis of the RC states:

"For a company or juristic partnership incorporated under foreign laws which has an employee, an agent or a go-between for carrying on business in Thailand and as a result receives income or profits in Thailand, such company or juristic partnership shall be deemed to be carrying on business in Thailand and the person who acts as an employee, an agent or a go-between for the business, whether he is an individual or a juristic person, shall be deemed to be representative of the company or juristic partnership incorporated under foreign laws and shall have the duty and liability to file a tax return and tax payment in accordance with the provisions of this Part, with respect to only the abovementioned income or profits."

The practical implication of Section 76bis is obvious. If the real estate owned by a foreign entity is leased out through an on-shore agent, rental pool, etc., such agent or rental pool company could be deemed to be an "employee, an agent or a go-between" of such foreign entity. The result would be that the foreign entity would then be treated like a Thai entity with regard to the income derived from its real estate located in Thailand and its rental income would be subject to the same tax regime. Furthermore, the on-shore liability to file the tax return and pay the applicable tax on behalf of the off-shore entity would be on the said agent or rental-pool company.

It should be noted, however, that there are exceptions to the above. Depending on the jurisdiction in which such off-shore entity is registered such entity, and thereby any purported on-shore agent of the off-shore entity, may be able to invoke the provisions of a Double Taxation Agreement ("DTA") between the jurisdiction in which the off-shore entity was incorporated and Thailand, thus limiting the potential and scope of exposure to full Thai CIT on such rental income. Unfortunately, however, investors using off-shore entities from jurisdictions that do not have a DTA with Thailand such as the BVI, will not be entitled to invoke the protection. Both their off-shore entity and its on-shore agent have a significantly heightened exposure to full Thai CIT liability on rental income earned in Thailand."

As usual please seek professional advice on matters pertaining to legal and tax and make informed decisions.

Source: http://www.thephuketinsider.com/real_estate/tax-advisor-offshore-companies-rental-tax-exposure.php

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Source: http://olegugu.livejournal.com/48522.html

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Early Childhood Education | hot trends

Childhood education is the term commonly used to describe formal education and care of young children by other members of his family or in environments outside the home.For programming purposes, it was decided to extend the concept of early childhood to about 8 years. This age group is an opportunity to reinforce the perception of development as a continuum. It will facilitate interaction between preschool and primary school. The concept of basic education calls for early childhood and the key ?survival? qualities, ie the first two or three years of primary school.Terms of preschool and kindergarten to emphasize education over the age of 3-6 years. The terms ?early childhood learning,? ?early treatment? and ?early childhood? are comparable plan with early childhood. Terms of day care and children not covered by the educational aspects. Many childcare centers are now using multiple approaches. Create programs of study to fit into their daily routine to improve learning in education.The distinction between child care is the care and nursery schools are education, for example, have all but disappeared in countries that require employees in a variety of early childhood institutions to have a teacher. Child Boards organizing early childhood education nationally said that although it may raise the overall quality of children?s learning in a primary goal of all early childhood programs are ensuring a high level of care and nurturing young age and because of the emotional and physical needs of children. But it is necessary to distinguish between support and learning of the locomotive. One involves the development of rudimentary tools characterized babies, the second refers to the hand-eye coordination.As parents, you may have many questions, such as early childhood education does it mean? and why children need to learn how to ?soon? to help those most in school and thrive in life?According to Dr. James Heckman won the Nobel Prize in Economics expertise Economics Human Development is the foundation for later learning. Early Learning creates more learning. ?If you plant seeds in soil and water seeding what you get is a tree with a solid foundation that can endure. The human potential must be developed and maintained in the early stages. If you want to build a better future for your child, you develop the skills they need to maintain in the future.The early children education much more interaction between researchers e. Children will be taught in the allocation and, alternatively, friends, and develop their language and numeracy. By the end of 3 years of age a child is expected to collect and put away ? the one he used. Ideally, pre-school classroom, things are arranged so that children can take things they need to start a game or complete a project and after the game / project is finished you can take these things back. In short, the early childhood education must include a disability component of appropriate training.

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Source: http://hottrends.wikiaspace.com/2011/09/21/early-childhood-education/

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Study: Dialysis 3 times weekly might not be enough (AP)

LOS ANGELES ? A major study challenges the way diabetics and others with failing kidneys have been treated for half a century, finding that three-times-a-week dialysis to cleanse the blood of toxins may not be enough.

Deaths, heart attacks and hospitalizations were much higher on the day after the two-day interval between treatments each week than at other times, the federally funded study found.

The president of the National Kidney Foundation said she was "very troubled" by the results published in Thursday's New England Journal of Medicine.

"We could be doing a better job for our dialysis patients" and that might mean doing it more often, said Dr. Lynda Szczech, a Duke University kidney specialist who had no role in the study.

Kidneys rid the body of waste and fluids. Most of the 400,000 Americans with failing kidneys stay alive by getting their blood purified by a machine three days a week at dialysis clinics ? usually on Mondays, Wednesdays and Fridays or on Tuesdays, Thursdays and Saturdays. In both cases, there's a two-day break between the last session of the week and the next one.

The three-day dialysis schedule has been around since the mid-1960s and gives patients a weekend break from the grueling hours of being hooked up to a machine.

However, doctors have suspected that the two-day hiatus between treatments was risky, and smaller studies have found more heart-related deaths on the day after the gap.

"All the fluids and toxins are built up to the highest extent on Monday morning right before dialysis," said Dr. Anthony Bleyer of Wake Forest Baptist Medical Center in North Carolina, who has done similar studies.

The latest research, funded by the National Institutes of Health, is the largest yet. It was done by Dr. Robert Foley of the University of Minnesota and colleagues. All reported receiving fees from dialysis clinics and suppliers.

The team analyzed medical records of 32,000 people who had in-center dialysis three times a week from 2005 through 2008. The average age was 62 and a quarter had been on dialysis for a year or less. After about two years of follow-up, 41 percent had died, including 17 percent from heart-related causes.

Monday was the riskiest day for people on a Monday-Wednesday-Friday schedule. For those on a Tuesday-Thursday-Saturday schedule, the riskiest day was Tuesday.

Researchers found a 22 percent higher risk of death on the day after a long break compared with other days of the week. Put another way: For every 100 people on dialysis for a year, 22 would die on the day after the long interval versus 18 on other days.

Hospital admissions for stroke and heart-related problems more than doubled on the day after a long break than on other days ? 44 versus 20 for every 100 people treated.

Fixing this problem, however, could be daunting for patients, busy dialysis centers and insurers and it would require a rethinking of how dialysis is currently delivered.

Medicare covers the cost of dialysis, regardless of age, spending about $77,000 annually per person. It covers thrice-weekly treatment, but people can get a fourth session if needed.

Dr. Paul Eggers of the National Institute of Diabetes and Digestive and Kidney Diseases said adjusting how dialysis is done "would require some fairly convincing evidence. I'm not sure this one study would be sufficient to change" standard practice.

Kidney expert Dr. Eli Friedman of SUNY Downstate Medical Center in New York, said he's in favor of every-other-day dialysis or even daily dialysis. But it would mean "a multibillion dollar change," said Friedman, who launched the country's first federally funded dialysis center.

A clinic operator said increasing treatments would require additional staff. And patients also would have to be willing to come in more often.

"They don't even like coming in three times a week. It's completely understandable. It's not fun," said Dr. Allen Nissenson, chief medical officer at DaVita, which runs more than 1,600 clinics around the country.

There has been recent interest in more frequent dialysis after studies hinted that it made people feel healthier.

This year, Medicare started giving clinics a financial incentive to teach patients to do dialysis at home, allowing them to cleanse their blood more often. But this option is not for everyone. It requires intense training and patients need a helper at home.

Unless rules change, Wake Forest's Bleyer said people can take simple steps to reduce their risk by not drinking too much fluid between long dialysis breaks and eating a healthy diet.

"Patients must be a little more careful on the weekend than on other days of the week," he said.

Carol Thomas, who has been on dialysis since 2007, watches her water intake especially on weekends and avoids dairy, beans and nuts, which are high in certain nutrients that can cause complications.

Thomas, of Sacramento, Calif., said home dialysis is not an option because she doesn't have someone to help her. Would she make the trip for dialysis more often if given the choice?

"It's an inconvenience, but probably if it meant lengthening my life," the 69-year-old said.

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Online:

New England Journal: http://www.nejm.org

Kidney disease information: http://kidney.niddk.nih.gov

National Kidney Foundation: http://www.kidney.org

American Association of Kidney Patients: http://www.aakp.org

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Alicia Chang can be followed at: http://twitter.com/SciWriAlicia

Source: http://us.rd.yahoo.com/dailynews/rss/topstories/*http%3A//news.yahoo.com/s/ap/20110921/ap_on_he_me/us_med_dialysis_danger

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